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Popular Weight-Loss Drugs: A Dual Therapy for Obesity and Male Hormone Health

减肥新药或可提升男性睾酮且守护生育力

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Many overweight men struggle with low testosterone and impaired fertility. In a controlled experiment, an antidiabetic medication was given to obese men with hypogonadism. Their testosterone levels rose noticeably, and the proportion of healthy sperm doubled. Meanwhile, men on standard testosterone therapy saw their sperm counts decline. Additional analyses of patient records suggest these drugs can boost testosterone by a considerable margin.

The link between obesity and low testosterone is well established. Fat cells contain an enzyme called aromatase, which transforms testosterone into estrogen. At the same time, excess weight disturbs signals from the pituitary gland, telling the testes to produce less hormone. This dual disruption explains why obese men often have reduced testosterone levels. But the good news is that this state is reversible. When men lose weight through medication, improved diet, or exercise, the enzyme activity drops and pituitary function often returns to normal.

Inspired by Scientific American reporting · Rewritten by Vocabsavvy · Vocabsavvy Original (inspired-by attribution)

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